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NADPH oxidases, reactive oxygen species, and the kidney: friend and foe

Glutathione peroxidase converts hydrogen peroxide into water before it can produce damaging free radicals

3 Crucially, the same study pointed to a neural, vagally mediated mechanism: the effect had the signature of vagal inhibition rather than a direct action on gastric smooth muscle

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57,287 Paz et al

61 Finally, the effector protein, typically a caspase enzyme, is recruited to the complex and activated, initiating downstream signaling events that lead to inflammation and cell death